Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cells microvesicles stabilize endothelial barrier function partly mediated by hepatocyte growth factor (HGF)

Fig. 6

MSC-MVs upregulate endothelial VE-cadherin and occludin protein expression via HGF. a, b Image and quantitative results of VE-cadherin protein expression in the endothelial cells. a, c Image and quantitative results of occludin protein expression in the endothelial cells. The results showed that LPS stimulation of endothelial cell reduced the expression of VE-cadherin and occludin protein and that these effects were inhibited by MSCs and MSC-MVs. However, the effect of MSC-MVs was significantly restrained after HGF gene knockdown. (n = 3, *p < 0.05, **p < 0.01 vs. control group; # p < 0.05 vs. LPS group; &p < 0.05 vs. MSC-MVs group). HGF hepatocyte growth factor, LPS lipopolysaccharide, MSC-CM mesenchymal stem cells conditioned medium, MSC-MVs mesenchymal stem cells microvesicles, MSCs, mesenchymal stem cells

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512