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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Local application of IGFBP5 protein enhanced periodontal tissue regeneration via increasing the migration, cell proliferation and osteo/dentinogenic differentiation of mesenchymal stem cells in an inflammatory niche

Fig. 3

rhIGFBP5 rescued the impaired functions of IGFBP5-silenced-PDLSCs in inflammatory condition. TNFα (10 ng/ml) was used to treat PDLSCs. a, b The scratch-simulated migration assay results. Scale bar: 100 μm. c, d The Transwell chemotaxis assay results. Scale bar: 50 μm. e ALP activity. f Alizarin red staining. g Cell Counting Kit-8 assay results. One-way ANOVA was used to verify statistical significance. Error bars represent SD (n = 3). *P ≤ 0.05; **P ≤ 0.01. rhIGFBP5 recombinant human insulin-like growth factor binding protein 5

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Stem Cell Research & Therapy

ISSN: 1757-6512