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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: miR-524-5p of the primate-specific C19MC miRNA cluster targets TP53IPN1- and EMT-associated genes to regulate cellular reprogramming

Fig. 1

Overexpression of mir-524 precursor promotes OKSM-driven iPSC generation at the early stage of induction. a High degree of sequence homology (bold letters) between miR-524-5p and miR-520d-5p. b Upregulated miR-524-5p levels in OSKM/mir-524 co-transduced relative to OSKM-transduced HFF-1 cells. *p < 0.05. c ESC-like morphology of two representative colonies formed at passage 1. d ESC-like alkaline phosphatase (AP)-positive colonies on day 14 that co-stained with Nanog on day 18 post-transduction with OSKM only, or OSKM in combination with either the blank vector CD511 or with a mir-524 precursor construct

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Stem Cell Research & Therapy

ISSN: 1757-6512