Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension

Table 1 Histopathological score for pulmonary arterial hypertension

	Pre-acinar artery				Intra-acinar artery
	Medial hypertrophy	Concentric laminar intimal thickening	Dilatation lesions	Medial hypertrophy	Concentric laminar intimal thickening	Dilatation lesions
CTRL-SAL	1 (1–1)	1 (1–1)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)
CTRL-MSC	1 (1–1)	1 (1–1)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)
MCT-SAL	4 (4–4)*	4 (4–4)*	2 (1–3)*	3 (2–4)*	3 (2–4)*	2 (2–2)*
MCT-MSC	2 (1–3)^†	2 (2–2)	1 (0–1)	2 (1–3)^†	2 (0–2)^†	2 (1–3)

Classification of vasculopathies in pulmonary hypertension. Values presented as median (interquartile range) of seven animals/group
CTRL control, MCT monocrotaline, SAL saline
*Significantly different from CTRL-SAL group (p < 0.0167)
^†Significantly different from MCT-SAL group (p < 0.0167)

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