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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation

Fig. 2

Cell morphology and chondrogenic property of M-MSCs in vitro. a Cell morphology in two-dimensional culture and staining results of Safranin O or type II collagen (Col II) after chondrogenic differentiation for 21 days in three-dimensional cell pellets. b Size of pellets (diameter). c Expression levels of chondrogenic markers (Col2a1, Acan, and Sox9) and hypertrophic markers (Col10a1 and MMP13) determined by qRT-PCR assays. Values represent means ± SD (n = 3 donors with three replicates per donor). *P < 0.05, **P < 0.01, ***P < 0.001, vs. MSCs. Scale bar = 100 μm. M-MSC manipulated mesenchymal stem cell, MSC mesenchymal stem cell

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