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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation

Fig. 7

Repair effect of engineered cartilage in an osteochondral defect rat model after 2 months of implantation. Cell-seeded MeHA hydrogels were incubated in chondrogenic medium and pretreated with free loading (FL) or dynamic loading (DL) in the bioreactor for 14 days before implantation. a Representative gross view and histology of distal femoral samples stained with Safranin O and fast green (S & G) or immunohistochemically stained with type II collagen (Col II) and green fluorescent protein (GFP). White arrows point to the defect sites. Black arrows point to the GFP-positive area. Dashed lines indicate the interface of native tissue and the defect sites (d). b Semi-quantitative data (Wakitani score) after treatments. c Semi-quantitative data of the Col II-positive area in the defect area. Values represents means ± SD (n = 10). *P < 0.05, vs. MSCs + FL. M-MSC manipulated mesenchymal stem cell, MSC mesenchymal stem cell

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