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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Hypoxia preconditioning promotes cardiac stem cell survival and cardiogenic differentiation in vitro involving activation of the HIF-1α/apelin/APJ axis

Fig. 6

Alterations of molecules and specific markers of cardiogenic differentiation after inhibition of the HIF-1α/apelin/APJ axis. (a) Western blot and (b) qRT-PCR analysis of the molecules in the HIF-1α/apelin/APJ axis after relevant siRNA interference. c Changes of cardiogenic differentiation specific genes including α-SA and cTnT after the blockage of the HIF-1α/apelin/APJ axis. **p < 0.01 vs normoxia, ## p < 0.01 vs HP, ††p < 0.01 vs NC. HP: hypoxia preconditioning, HIF: hypoxia-inducible factor, apelin: ligand for putative receptor protein related to angiotensin receptor AT1, APJ: putative receptor protein related to angiotensin receptor AT1, NC negative control

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