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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice

Fig. 7

Adjudin-pretreated NSCs inhibited M1 activation but promoted M2 expression after I/R. Immunofluorescence staining for CD16 and Arg-1 showed activation of M1 and M2 microphages in sham, PBS, nonpretreated NSC, and adjudin-pretreated NSC groups at 3 days after cell transplantation (a, d). Scale bar =50 μm. Quantification of MI/M2 positive cells in each group (b, e). Relative mRNA expression level of CD16 and Arg-1 checked using RT-PCR normalized to Rplp0 (c, f). n = 5 in each group. Data are mean ± SEM. *P < 0.05, **P < 0.01. NSC neural stem cell, PBS phosphate-buffered saline

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