Fig. 2
From: Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury
Tissue-to-air space ratio on postnatal day (PND) 7 and PND14 (n = 6–8). a Dose effect of hAEC administration. At PND7, tissue-to-air space ratio was decreased in the saline-treated injured group, but this was mitigated by the two highest doses of hAECs in a dose-dependent manner. b Early intravenous injection of hAECs restored the tissue-to-air space ratio on PND14. c Early intratracheal injection of hAECs restored the tissue-to-air space ratio on PND14. d, e Early intravenous hAEC administration normalised the tissue-to-air space ratio; however, late intravenous hAEC administration also improved lung structure but remained lower than control on both PND7 (d) and PND14 (e). Data expressed as mean ± standard error of mean (SEM). Statistical significance determined with one-way ANOVA accompanied by the Bonferroni post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. hAEC human amnion epithelial cell, IT intratracheal, IV intravenous