Fig. 3

SVF and PRP of SSc patients and healthy subjects show different paracrine factors. a Growth factors and cytokines released by undigested PRP (right panel) collected from healthy donors and SSc patients. Bars represent mean ± SD of three independent experiments performed on three different samples from both healthy subjects and SSc patients. b Analysis of growth factor and cytokine levels in undigested SVF (right panel) collected as in a. Bars represent mean ± SD of three independent experiments performed on four different samples from both healthy subjects and SSc patients. c Analysis of HGF and VEGF levels in the SVF from healthy subjects and SSc patients, and PRP from SSc patients. Data are mean ± SD of three independent experiments performed using four different biological samples from both healthy subjects and SSc patients. *p < 0.05, ***p < 0.001. AD-MSC adipose-derived mesenchymal stem cell, HGF hepatocyte growth factor, PRP platelet-rich plasma, SSc systemic sclerosis, SVF stromal vascular fraction, VEGF vascular endothelial growth factor