Table 1 Gene ontology analysis
From: miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors
GO biological process | No of genes | p value |
|---|---|---|
Gene sets predicted to be upregulated following downregulation of at least three miRNAs (248 genes in analysis) | ||
Central nervous system development | 31 | 5.15E-05 |
Regulation of cellular protein metabolic process | 49 | 5.15E-05 |
Regulation of growth | 25 | 5.15E-05 |
Cell division | 24 | 5.15E-05 |
Regulation of cell cycle | 34 | 5.15E-05 |
Regulation of translation | 15 | 0.000127 |
Negative regulation of cellular metabolic process | 48 | 0.000127 |
Negative regulation of apoptotic process | 27 | 0.000127 |
Regulation of protein metabolic process | 51 | 0.000127 |
Neurogenesis | 27 | 0.000127 |
Gene sets predicted to be targeted (downregulated) by at least two upregulated miRNAs (164 genes in analysis) | ||
Gland development | 13 | 0.00222 |
Positive regulation of cell proliferation | 20 | 0.00701 |
Negative regulation of transcription from RNA polymerase II promoter | 15 | 0.00831 |
Positive regulation of cell migration | 10 | 0.00831 |
Regulation of chromosome organization | 7 | 0.00831 |
Regulation of cell proliferation | 28 | 0.00831 |
Negative regulation of apoptotic process | 17 | 0.00831 |
Negative regulation of programmed cell death | 17 | 0.00831 |
Positive regulation of developmental processes | 19 | 0.00831 |
Positive regulation of cellular component organization | 15 | 0.00831 |