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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: TGFβ3 recruits endogenous mesenchymal stem cells to initiate bone regeneration

Fig. 3

TGFβ3 upregulated MCP1 secretion from vascular cells by TβRII/Smad3 signaling. a Secretion of MCP1 and SDF1 from vascular cells in the coculture system hBMSCs and vascular cells with TGFβ3. b Secretion of MCP1 from hBMSCs, hUVECs, and hUASMCs in different systems. c Expression of TβRII in hUVECs and hUASMCs induced by TGFβ3 assessed by western blot analysis. d Expression of p-Smad3 and Smad3 in hUVECs and hUASMCs induced by TGFβ3 assessed by western blot analysis. **P < 0.01, ***P < 0.005, ****P < 0.001. hUASMC human umbilical artery smooth muscle cell, hUVEC human umbilical vein endothelial cell, MSC mesenchymal stem cell, TGFβ3 transforming growth factor beta-3

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