Table 1 Cell therapy and tissue engineering studies from the ICREC laboratory on UCBMSCs, cATMSCs, and the AGTP
From: Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?
Study | MSC | Model | Delivery method | Results | Biosecurity |
|---|---|---|---|---|---|
Prat-Vidal et al. (2007) [33] | UCBMSC | In vitro | – | Isolation and characterization | – |
Roura et al. (2010) [34] | UCBMSC | In vitro | – | No cardiomyogenic differentiation | – |
UCBMSC | Acute MI mice | Fibrin patch | Reduced infarct size, larger vessels in myocardial area, and improved cardiac function | No mortality | |
Bayes-Genis et al. (2010) [22] | cATMSC | Acute MI mice and rat | Intramyocardial | Cardiomyogenic and endothelial differentiation, improved cardiac function, reduced infarct size, increased vessel density | No mortality, No teratoma formation |
Perea-Gil et al. (2015) [27] | cATMSC | In vitro | – | Dose-dependent suppression of T-cell alloproliferation | – |
Llucià -Valldeperas et al. (2015) [39] | cATMSC | In vitro | – | Higher constitutive expression of Cx43, α-actinin, SERCA2, and GATA4 | – |
Llucià -Valldeperas et al. (2017) [40] | cATMSC | Acute MI mice | Fibrin patch | Improved cardiac function, increased myocardial vessel density | No mortality |
Gálvez-Montón et al. (2011) [58] | cATMSC | Acute MI swine | AGTP | Improved cardiac function, reduced infarct size, flap-myocardium vascular connections | No mortality |
Gálvez-Montón et al. (2013) [59] | cATMSC | Chronic MI swine | AGTP | Reduced infarct size, flap-myocardium vascular connections | No mortality |
Prat-Vidal et al. (2014) [53] | cATMSC | Acute MI swine | Pericardial scaffold | Reduced infarct size | No mortality |
Bayes-Genis et al. (2016) [62] | cATMSC | Chronic MI human | AGTP | Partial efficacy | No mortality |
Perea-Gil et al. (2016) [56] | cATMSC | Acute MI swine | Myocardial scaffold | Improved cardiac function, reduced infarct size, less fibrosis, higher myocardial vessel density | No mortality, no rejection, no arrhythmias |
Gálvez-Montón et al. (2017) [60] | cATMSC | Acute MI swine | Pericardial scaffold | Improved cardiac function, reduced infarct size, less inflammation and fibrosis | No mortality |