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Table 1 Cell therapy and tissue engineering studies from the ICREC laboratory on UCBMSCs, cATMSCs, and the AGTP

From: Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?

Study MSC Model Delivery method Results Biosecurity
Prat-Vidal et al. (2007) [33] UCBMSC In vitro Isolation and characterization
Roura et al. (2010) [34] UCBMSC In vitro No cardiomyogenic differentiation
Roura et al. (2012) [28, 36] UCBMSC Acute MI mice Fibrin patch Reduced infarct size, larger vessels in myocardial area, and improved cardiac function No mortality
Bayes-Genis et al. (2010) [22] cATMSC Acute MI mice and rat Intramyocardial Cardiomyogenic and endothelial differentiation, improved cardiac function, reduced infarct size, increased vessel density No mortality,
No teratoma formation
Perea-Gil et al. (2015) [27] cATMSC In vitro Dose-dependent suppression of T-cell alloproliferation
Llucià-Valldeperas et al. (2015) [39] cATMSC In vitro Higher constitutive expression of Cx43, α-actinin, SERCA2, and GATA4
Llucià-Valldeperas et al. (2017) [40] cATMSC Acute MI mice Fibrin patch Improved cardiac function, increased myocardial vessel density No mortality
Gálvez-Montón et al. (2011) [58] cATMSC Acute MI swine AGTP Improved cardiac function, reduced infarct size, flap-myocardium vascular connections No mortality
Gálvez-Montón et al. (2013) [59] cATMSC Chronic MI swine AGTP Reduced infarct size, flap-myocardium vascular connections No mortality
Prat-Vidal et al. (2014) [53] cATMSC Acute MI swine Pericardial scaffold Reduced infarct size No mortality
Bayes-Genis et al. (2016) [62] cATMSC Chronic MI human AGTP Partial efficacy No mortality
Perea-Gil et al. (2016) [56] cATMSC Acute MI swine Myocardial scaffold Improved cardiac function, reduced infarct size, less fibrosis, higher myocardial vessel density No mortality, no rejection, no arrhythmias
Gálvez-Montón et al. (2017) [60] cATMSC Acute MI swine Pericardial scaffold Improved cardiac function, reduced infarct size, less inflammation and fibrosis No mortality
  1. ICREC Insuficiència Cardíaca i Regeneració Cardíaca, UCBMSC umbilical cord blood mesenchymal stem cell, cATMSC cardiac adipose tissue mesenchymal stem cell, MI myocardial infarction, AGTP adipose graft transposition procedure