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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells

Fig. 5

Safety comparison between 6F/BM1-4C and a traditional episomal induction system. a Changes in morphology in the iPSC generation process using the 4F2L-6C and 6F/BM1-4C systems. b Abnormal karyotype rates of iPSCs generated using the 4F2L-6C (n = 64) and 6F/BM1-4C (n = 65) systems. *P < 0.05 (P = 0.017). c Quantitative real-time PCR assay for Sirt1, p53, TERT, CHK1 expression. *P < 0.05 (P = 0.034). Scale bars, 100 μm. D day

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Stem Cell Research & Therapy

ISSN: 1757-6512