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Table 2 Specific changes in cell karyotypes using the 4F2L-6C and 6F/BM1-4C systems

From: Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells

No. Method Karyotype change(s)
7 4F2L-6C 88 < 4n>,XXXX,-X,-19,-18,-18[20]
13 4F2L-6C 46 < 2n>,XX,der(2)ins(2;?)(P25;?)[20], 89 < 4n>,XXXX,-XX,-5[20]
14 4F2L-6C 87 < 4n>,XXXX,-XX,-15,-19,-19[20]
18 4F2L-6C 89 < 4n>,XXXX,-17,-17,-15?
19 4F2L-6C 46 < 2n>,XX,der(13)t(13;1)(p13;q11 → q44)[20]
22 4F2L-6C 45 < 2n>,XX,-17[20]
29 4F2L-6C 91 < 4n>,XXXX,der(15)t(15;22)(p13;p13 → q13),-5[20]
37 4F2L-6C 46 < 2n>,XX,+9[20]
40 4F2L-6C 45 < 2n>,XX,-7[20]/-17[20]/-21[20], 47 < 2n>,XX,+15[20]
49 4F2L-6C 45 < 2n>,XX,-X[20], 92 < 4n>,XXXX,der(17)ins(17;?)(p13;?)
54 4F2L-6C 92 < 4n>,XXXX,-X,+11[20]
57 4F2L-6C 45 < 2n>,XX,-9[20]/-17[20]
60 4F2L-6C 92 < 4n>,XXXX,-X,+22[20]
3 6F/BM1-4C 90 < 4n>,XXXX,-16,-16, 45 < 2n>,XX,-22[20]/-20[20]
15 6F/BM1-4C 47 < 2n>,XX,+9[20]
59 6F/BM1-4C 48 < 2n>,XX,+21,+22, 90 < 4n>,XXXX,-18,-20[20]/-21,-22[20]
61 6F/BM1-4C 47 < 2n>,XX,+X[20]/+9[20]
  1. 4F2L-6C episomal-induced system containing six reprogramming factors (Oct4, Sox2, Klf4, c-Myc, SV40-LT, and Lin28) and six compounds (PD, CHIR, NaB, Par, thi, and A83-01), 6F/BM1-4C episomal-induced system containing six reprogramming factors (Oct4, Glis1, Klf4, Sox2, L-Myc, and miR-302cluster) and four compounds (PD, CHIR, NaB, and Par), [20] 20 metaphases, <2n > abnormal frequency ≥ 3 metaphases, <4n > abnormal frequency ≥ 15%
  2. Reference to International System for Human Cytogenetic Nomenclature 2009