Fig. 3
From: Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment
CAPE promoted short-term engraftment of HSPCs in the BM. a Morphology of CFU-S12. Lethally irradiated mice were treated with vehicle or 3.0 mg/kg CAPE from day –1 to day +1 and were injected with 1.5 × 105 BM MNCs on day +1. Spleens were isolated from these mice on day 12 after BMT. b Total numbers of CFU-S12 counted. n = 8 in blue, n = 6 in red. c, d Total CFUs and different types of CFU numbers generated from 1 × 105 BM MNCs (n = 5). BM MNCs harvested for CFU assays on day 12 after BMT. Blue indicates vehicle-treated group, red indicates CAPE-treated group; experiments repeated three times. Data presented as mean ± SD. **P < 0.01, ***P < 0.001, CAPE vs vehicle. BM bone marrow, CAPE caffeic acid phenethyl ester, CFU-G granulocyte colony-forming units, CFU-M macrophage colony-forming units, CFU-GEMM granulocyte–erythroblast–macrophage–megakaryocyte colony-forming units, CFU-GM granulocyte–macrophage colony-forming units, MNC mononuclear cell