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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment

Fig. 6

HIF-1α inhibitor PX-478 blocked CAPE-enhanced HSPC homing. a Total CFU number generated from 5 × 105 BM MNCs (n = 5). Lethally irradiated mice were injected intraperitoneally with vehicle or 3.0 mg/kg CAPE from day –1 to day +1, and received BMT on day +1. For some mice, 5 mg/kg PX-478 was administered just after CAPE injection. Twenty hours after BMT, BM MNCs were harvested and cultured for CFU assays. Experiment repeated three times. b Homing efficiency calculated by comparing the homed CFU numbers with the initially injected CFU numbers. Data presented as mean ± SD. ***P < 0.001, CAPE vs Vehicle, CAPE vs CAPE + PX-478. BM bone marrow, CAPE caffeic acid phenethyl ester, CFU colony-forming unit, MNC mononuclear cell

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