Fig. 7
From: Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment
Graphic representation of the regulation mechanism of CAPE in the improvement of HSPC homing. Left: process of HSPC homing and engraftment in the BM, including HSPC rolling in vessels, migrating across BMECs and lodging in the BM niche. Right: CAPE induces expression of HIF-1α protein, activating downstream SDF-1α and VEGF-A gene expression in BMECs. Thus, CAPE creates a better chemotactic and survival environment for transplanted HSPCs and promotes HSPC homing and engraftment. Picture drawn by Dr Hailiang Li. BMEC bone marrow endothelial cell, CAPE caffeic acid phenethyl ester, HIF-1α hypoxia inducible factor-1α, HSPC haematopoietic stem/progenitor cell, SDF-1α stromal cell-derived factor 1α, VEGF vascular endothelium growth factor