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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice

Fig. 6

TXN reduced γH2AX and p38 expression after TBI. Lin– BMCs were isolated and culture with appropriate growth factor as described in the text. Lin– BMCs were irradiated with 3 Gy, and treated with and without thioredoxin (TXN) for 1 and 4 h. a Western blot analysis of p38, phospho-p38, γH2AX, and GAPDH protein expression. Quantitative densitometry of the protein expressions of b phospho-p38 and c γH2AX. d Primary fibroblasts were irradiated with 3 Gy with and without TXN for 1 h and stained with γH2AX foci (red) and DAPI (blue). Data are shown as the mean ± SD. *P < 0.05; **P < 0.01. n.s., no statistical difference. IR ionizing radiation, n.s. not significant, UT untreated

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