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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs

Fig. 2

Morphological features of smDCs, mDCs, imDCs, and regDCs observed with a fully automated and inverted microscope (×200). smDCs and regDCs were either round or oval and their lengths of dendrites were between those of imDCs (a) and mDCs (c). Morphology of smDCs (b) and regDCs (d) was similar. Quantitative data about cell morphology as diameter shown in right panel. Expression of MHC-II, CD40, CD80, and CD86 on the surface of smDCs, mDCs, imDCs, and regDCs analyzed by flow cytometer. smDCs and regDCs both expressed medium levels of MHC-II, CD40, CD80, and CD86, which were higher than their corresponding levels in imDCs but lower than their corresponding levels in mDCs. (e). Quantitative data about the mean value of each immunophenotype shown in right panel. smDCs and regDCs also secreted high levels of inhibitory cytokines including TGF-β and IL-10, and low levels of inflammatory cytokines such as IL-2 (f). imDC immature dendritic cell, IL interleukin, mDC mature dendritic cell, MHC major histocompatibility complex, regDC regulatory dendritic cell, smDC semimature dendritic cell, TGF transforming growth factor

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