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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue

Fig. 4

DNA methylation status of Runx2 and PPARγ in ATSCs and BMSCs. DNA methylation status of Runx2 (a) and PPARγ (b) promoters in ATSCs and BMSCs were examed using sodium bisulfite sequencing. Top panel indicates CpG dinucleotide position of the Runx2 and PPARγ promoter regions. Each PCR product was subcloned and subjected to nucleotide sequencing analysis. Ten representative sequenced clones depicted by filled (methylated) and open (unmethylated) circles for each CpG site. ATSC: adipose tissue-derived MSC, BMSC: bone marrow-derived MSC, MSC: mesenchymal stem cell, PPARγ: peroxisome proliferator-activated receptor gamma, Runx2: runt-related transcription factor 2

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