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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Pellet coculture of osteoarthritic chondrocytes and infrapatellar fat pad-derived mesenchymal stem cells with chitosan/hyaluronic acid nanoparticles promotes chondrogenic differentiation

Fig. 2

Cell morphology and cell labeling after 1 week of chondrogenic coculture. a Phase contrast images of IPFP mesenchymal stem cells (MSCs) (left), articular chondrocytes (ACs) (middle), and coculture of MSCs and ACs (right) in monolayer. The green arrow points to ACs, and the red arrow points to MSCs in coculture. b Macroscopic observation of MSCs (left), ACs (middle), and coculture of MSCs and ACs (right) in pellets. Arrows point to cell sediments after 1 week of culture; inserts illustrate the size of the pellets. c MSCs were labeled with DiI (red) and ACs were labeled with Dio (green) in monolayer (left) and pellet (middle) coculture. After 1 week of coculture, the labeled cells were counted, and the ratio of AC number to MSC number was calculated (right). Data are presented as mean ± SD. *P < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512