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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage

Fig. 7

Schematic diagram illustrated the two possible mechanisms responsible for the restoration effects of hAECs-based therapy. (1) Left side showed the transdifferentiation ability of hAECs into FSHR-positive granulosa cells in chemotherapy-induced POF/POI model, which was considered as a small probability event. (2) Right side showed that hAECs-secreting cytokines exerted protective and restorable function on ovarian microenvironment against chemotherapy-induced damage via reducing apoptosis, promoting angiogenesis and regulating follicular development

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