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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction

Fig. 6

miR-133 enhanced survival of MSCs in vivo and downregulated expression of snail 1. Survival of MSCs indicated by CM-Dil (chloromethylbenzamido) and expression level of snail 1 analyzed by Q-PCR. a Fluorescent photographs of surviving MSCs with red fluorescence. b miR-133 level in exosome isolated from MSC culture supernatant. c Western blot analysis of CD63 in exosome. d Snail 1 3′UTR contains predicted miR-133 binding sites, which are conserved among species. e Relative expression of snail 1 in cardiomyocytes cocultured with different MSCs. f Relative expression of snail 1 in left ventricular tissue at 7 and 28 days after MI. *p < 0.05, **p < 0.01, ***p < 0.001. CON control, LV left ventricle, MSC mesenchymal stem cell, NC negative control, PBS phosphate-buffered saline

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