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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Pentosan polysulfate binds to STRO-1+ mesenchymal progenitor cells, is internalized, and modifies gene expression: a novel approach of pre-programing stem cells for therapeutic application requiring their chondrogenesis

Fig. 1

Kinetics of uptake of various concentrations of pentosan polysulfate (PPS) (0.5, 1.0, 2.5, 5, and 10 μg/ml/well) by 3.0 × 105 MPCs/well maintained in monolayer cultures for 24 h. The concentration of PPS remaining in the culture media after 0.25, 0.50, 2, 6, 20, and 24 h was determined using ELISA. Note the rapid decline in PPS media concentrations within 2 h of culture followed by shedding of PPS into the media with the 0.5 and 1.0 μg/ml concentrations. The media concentration of 5.0 μg/ml exhibited the highest uptake by the MPCs over the 24-h culture period

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Stem Cell Research & Therapy

ISSN: 1757-6512