Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

Table 1 Clinical studies testing the efficacy of MSCs in AKI and CKD

Condition	ID	Title	Link	Status
AKI	NCT01275612	Mesenchymal stem cells in cisplatin-induced acute renal failure in patients with solid organ cancers	https://clinicaltrials.gov/ct2/show/NCT01275612	Recruiting
	NCT00733876	Allogeneic multipotent stromal cell treatment for acute kidney injury following cardiac surgery	https://clinicaltrials.gov/ct2/show/NCT00733876	Completed
	NCT01602328	A study to evaluate the safety and efficacy of AC607 for the treatment of kidney injury in cardiac surgery subjects	https://clinicaltrials.gov/ct2/show/NCT01602328	Terminated
CKD	NCT02166489	Mesenchymal stem cells transplantation in patients with chronic renal failure due to polycystic kidney disease	https://clinicaltrials.gov/ct2/show/NCT02166489	Completed
	NCT01843387	Safety and efficacy of mesenchymal precursor cells in diabetic nephropathy	https://clinicaltrials.gov/ct2/show/NCT01843387	Completed
	NCT02266394	Hypoxia and inflammatory injury in human renovascular hypertension	https://clinicaltrials.gov/ct2/show/NCT02266394	Recruiting
	NCT02409940	To elucidate the effect of mesenchymal stem cells on the T-cell repertoire of the kidney transplant patients	https://clinicaltrials.gov/ct2/show/NCT02409940	Ongoing
	NCT00658073	Induction therapy with autologous mesenchymal stem cells for kidney allografts	https://clinicaltrials.gov/ct2/show/NCT00658073	Completed

ISSN: 1757-6512