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Table 4 Experimental studies testing the efficacy of MSC-derived EVs RVD-CKD

From: Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

Type of model Species Intervention Administration method Main findings Reference
In vivo model of coexisting metabolic syndrome and RVD Pig Autologous adipose tissue MSC-derived EVs Intrarenal • EVs decreased renal inflammation
• Improved medullary oxygenation and fibrosis, and restored renal blood flow and glomerular filtration rate
• Renoprotective effects were partly mediated by IL-10
Eirin et al. 2017 [55]
  1. CKD chronic kidney disease, EV extracellular vesicle, MSC mesenchymal stem cell, RVD renovascular disease