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Table 6 Experimental studies testing the efficacy of MSC-derived EVs in STN-CKD

From: Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges

Type of model Species Intervention Administration method Main findings Reference
In vivo Mouse Allogenic bone marrow MSC-derived EVs Intravenous • EVs improved renal function
• Decreased renal fibrosis, inflammation, and tubular atrophy
He et al. 2012 [60]
  1. CKD chronic kidney disease, EV extracellular vesicle, MSC mesenchymal stem cell, STN subtotal nephrectomy