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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: RETRACTED ARTICLE: Effects of hPMSCs on granulosa cell apoptosis and AMH expression and their role in the restoration of ovary function in premature ovarian failure mice

Fig. 3

Effects of hPMSC transplantation on estrous cycles for pZP3-induced POF mice. Normal estrous cycles: a proestrus, b estrus, c metestrus, d diestrus. e Four patterns of estrous cycles were graded with the severity of abnormality (I–IV) as follows: I, normal; II, regular cycles with a shortened estrus; III, irregular cycles with a prolonged diestrus and normal or prolonged estrus; IV, no cyclicity. y axis represents the cycle day in proestrus or estrus (p-e) and metestrus or diestrus (m-d). Each circle (○) represents one mouse. Illustration is only represented by a mouse and the main purpose is to show the change of estrus cycle. f Total numbers of mice from each group categorized into the various estrous patterns (I–IV). **P < 0.01 indicates the statistically significant difference of the estrous cycle in mice with and without hPMSC transplantation. Data presented as mean ± SD (n = 24). hPMSC human placenta mesenchymal stem cell, POF premature ovarian failure

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