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Table 7 Areas of the brain showing increased metabolism in the PET scan performed in three patients corresponding to functional improvements

From: An open-label proof-of-concept study of intrathecal autologous bone marrow mononuclear cell transplantation in intellectual disability

Patient

Age (years)/gender

Areas of brain showing improvement in PET

Corresponding improvements observed

1

15/male

Frontal

Planning, problem-solving, command-following, cognitive skills, emotions

Mesial temporal region

Social participation, learning

Cerebellum

Balance and coordination

2

15/female

Cerebellum

Balance, coordination and fine motor activities

Frontal lobe

Command-following, understanding, planning, problem-solving

3

13/female

Frontal lobe

Learning ability, cognitive skills, decision-making

Amygdala

Social interaction, behaviour

Thalamus

Sensory interpretation, sleep and consciousness

  1. PET positron emission tomography