Fig. 5

Immunogenicity assay of human fetal GMSCs. a Human fetal GMSC lysates cocultured with human PBMCs, PHA + PMA-induced PBMCs used as positive control. After coculture for 24 and 48 h, there was no cell aggregation in the control and stem cell lysate groups, but the PHA + PMA group showed mass cell aggregation. b After coculture with human PBMCs for 24 and 48 h, IL-2 was measured by ELISA. Data presented as mean ± SD from four independent experiments (**P < 0.01). GMSC gingival mesenchymal stem cell, IL interleukin, PHA phytohemagglutinin, PMA phorbol myristate acetate