Fig. 3

The effect of human umbilical cord mesenchymal stem cell (huMSC) transplantation on spatial working memory, LTP, and DEP. a T-maze task. b Mean percentage of correct responses for the rewarded alternation test on the elevated T-maze. c The response changes of long-term potentiation (LTP) and depotentiation (DEP) in the DG region. The first 20 min of evoked responses are the baseline. The theta burst stimulation (TBS) was used to induce LTP recording for 1 h, and low-frequency stimulation (LFS) was used to induce DEP recording for 1 h. d Mean field excitatory postsynaptic potential (fEPSP) slopes of LTP of all time points. e Mean fEPSP slopes of DEP of all time points. All data are expressed as mean ± SEM, n = 6 per group. *P < 0.05, **P < 0.01, vs. AD-Veh; ^#P < 0.05, ^##P < 0.01, vs. huMSCs-shNC