Fig. 7

The effect of human umbilical cord mesenchymal stem cell (huMSC) transplantation on neurogenesis of the subgranular zone (SGZ) and the subventricular zone (SVZ). a–d Ki67 was detected by immunofluorescence staining and quantitative analysis by image J software in the SGZ and SVZ, respectively. e–h The effect of huMSC transplantation on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) secretion in the cortex and hippocampus by ELISA. All data are expressed as mean ± SEM, n = 3. Data were generated from three independent experiments. *P < 0.05, **P < 0.01, vs. AD-Veh; ^#P < 0.05, ^##P < 0.01, vs. huMSCs-shNC. DG dentate gyrus, LV lateral ventricle