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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells

Fig. 7

Rule-out tumorigenicity assay. Athymic BALB/c nude mice were injected subcutaneously with 5 × 105 Dox-induced dCas9-E bone marrow-derived mesenchymal stem cells (BM-MSCs) suspended in DMEM (FBS free). Positive control mice were injected with MGC-803 cells and sent to pathology analysis when tumors were ≤ 1.0 cm in diameter. Representative images (a) and hematoxylin and eosin staining (b) showed tumor formation after cell injection. sgRNA single-guide RNA

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