Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Fig. 3

Activation of the STAT3 signaling pathway during osteogenic differentiation in BM-MSCs. a STAT3 phosphorylation was markedly increased on day 7 to 14 of induction. b Extent of ARS staining in BM-MSCs on day 10 of osteogenic differentiation was reduced by AG490. c ALP staining and activity of BM-MSCs on day 10 of osteogenic differentiation were reduced by AG490. d Expression of osteoblastic markers in BM-MSCs, including Runx2, Osterix, OCN, and OPN, was inhibited by AG490. Data are presented as the means ± SD of 15 samples per group. *Indicates P < 0.05 compared to the day 0 group. IL-6 interleukin 6, IL-6R interleukin 6 receptor, OCN osteocalcin, OPN osteopontin

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512