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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Fig. 4

Exogenous IL-6 and sIL-6R promote osteogenic differentiation in BM-MSCs. a Extent of ARS staining in BM-MSCs was clearly increased by exogenous IL-6, sIL-6R or both. b ALP staining and activity of BM-MSCs were noticeably increased by exogenous IL-6 and sIL-6R. c Expression of osteoblastic marker genes in BM-MSCs was also promoted by exogenous IL-6 and sIL-6R. d STAT3 phosphorylation was markedly increased in response to stimulation with exogenous IL-6 and sIL-6R. Data are presented as the means ± SD of 15 samples per group. *Indicates P < 0.05 compared to the induction group. IL-6 interleukin 6, IL-6R interleukin 6 receptor,

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Stem Cell Research & Therapy

ISSN: 1757-6512