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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: PIP5K1α promotes myogenic differentiation via AKT activation and calcium release

Fig. 5

PIP5K1α regulates myogenic differentiation through two pathways. Activated PIP5K1α synthesizes more PIP2 to provide sufficient substrate for PI3K and PLC-γ. On one hand, PIP2 levels are constantly maintained at a high level to enable generation of IP3 required for the increase in intracellular calcium, which is necessary for initiating muscle differentiation. On the other, increased intracellular PIP2 of mammalian cell catalyzed by PIP5K1α subsequently affects the PI3K/AKT pathway. Activation of AKT was also important to myogenic differentiation. PI4P phosphatidylinositol-4-phosphate, PIP5KI phosphatidylinositol 4-phosphate 5-kinase, PI3K phosphatidylinositol 3-kinase, PLC phospholipase C, IP3 inositol 1,4,5-triphosphate, MEF2 myocyte enhancer factor-2. PIP(4,5)P2 Phosphatidylinositol 4,5-bisphosphate, PIP(3,4,5)P3 Phosphatidylinositol (3,4,5)-trisphosphate

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