Fig. 8From: Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig modelEffect of MSC-EV administration on virus titers in nasal swabs and lungs of pigs infected with SwIV. Eight-week-old pigs were mock infected or infected with swine/MN/08; H1N1 (SwIV). After 12 h, pigs were administered intratracheally with Dulbecco’s modified Eagle’s medium (DMEM) or MSC extracellular vesicles (EVs). Nasal swabs were collected from infected pigs at 1 and 3 days after EV administration (1DPEV and 3DPEV). At 3 days after EV administration, pigs were euthanized and lungs were harvested. Lung tissues were homogenized to prepare 10% lung lysate. Influenza virus shedding in nasal swabs and virus titers in lungs were determined by titration in MDCK cells. Values in each bar indicate mean virus titers of three pigs ± SDBack to article page