Table 1 Research on radiation-induced lung injury treated with MSC-based therapy
From: Mesenchymal stem cell-based therapy for radiation-induced lung injury
Study | Model | Cell type | Route | Efficacy results |
|---|---|---|---|---|
Wei et al. 2017 [46] | Mice | UC-MSCs transduced or not to express SOD3 | iv | The early treatment with UC-MSCs alone significantly reduced radiation pulmonary fibrosis, with further improvement by administration of SOD3-infected UC-MSCs |
Klein et al. 2017 [47] | Mice | BM-MSCs | iv | As a MSC-secreted factor, MSC-derived SOD1 is involved in the protective action of MSCs, and it plays a pivotal role against oxidative damage |
Chen et al. 2016 [45] | Mice | Mn-SOD-MSCs | iv | Mn-SOD-MSCs were successful in modulating RILI in mice |
Zhang et al. 2015 [29] | Human lung fibroblasts | UC-MSCs | Cocultured | Coculture of nHLFs with HU-MSCs weakened the radiation-induced activation of Wnt/β-catenin signaling. Wnt/β-catenin signaling became a potential therapeutic target for attenuating RILI |
Xia et al. 2016 [36] | Mice | BM-MSCs | iv | Low-dose hBM-MSC therapy in a dose-dependent manner better contributed to functional recovery in mice |
Jiang et al. 2015 [39] | Rats | AD-MSCs | iv | AD-MSCs could relieve RILI by reducing serum levels of IL-1, IL-6, and TNF-α, increasing levels of IL-10, and downregulating TGF-β1, α-SMA, and type 1 collagen levels in irradiated lung tissues |
Wang et al. 2014 [10] | Rats | UC-MSCs | iv | The UC-MSCs had definite therapeutic effects on acute radiation injury in rats |
Klein et al. 2016 [33] | Mice | BM-MSCs | iv | Therapy with BM-MSCs alleviated RILI and reduced the risk of lung metastasis |
Hu et al. 2013 [43] | Mice | Trx-1-overexpressing hUC-MSCs | iv | Trx-1-overexpressing hUC-MSCs prolonged the survival of injured mice |
Wang et al. 2013 [42] | Mice | AD-HGF-modified MSCs | iv | AD-HGF-modified MSCs did not reduce inflammation of the lungs but inhibited fibrosis |
Xue et al. 2013 [31] | Mice | AD-sTβR-MSCs | iv | MSCs and AD-sTβR-MSCs adopted the characteristics of alveolar type II (ATII) cells and significantly alleviated lung injury |
Kursova et al. 2009 [34] | Mice and humans | Autologous MSCs | iv | The increasing accumulation of transplanted stem cells in the lung tissue decreased the mortality rate of mice with RILI followed by thoracic irradiation and cell therapy with MSCs did not induce progression of the underlying oncological disease in clinical trial |