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Table 4 The top 10 UC-MSC research papers with the most citation frequency

From: Bibliometric analysis of global scientific activity on umbilical cord mesenchymal stem cells: a swiftly expanding and shifting focus

Title First author Journal Year Citations Citation frequency per year Main conclusion
Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue Kern Stem Cells 2006 1382 115.17 They compared MSCs derived from umbilical cord blood, bone marrow, and adipose tissue regarding morphology, the success rate of isolating MSCs, colony frequency, expansion potential, multiple differentiation capacity, and immune phenotype
Isolation of multipotent mesenchymal stem cells from umbilical cord blood Lee Blood 2004 819 58.5 They reported a novel method to obtain single cell-derived, clonally expanded MSCs that are of multilineage differentiation potential
Mesenchymal stem cells in the Wharton’s jelly of the human umbilical cord Wang Stem Cells 2004 665 47.5 UC-MSC express matrix receptors (CD44, CD105) and integrin markers (CD29, CD51), and can differentiate into cardiomyocytes
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood Wagner Experimental Hematology 2005 660 50.77 They provided a foundation for a more reproducible and reliable quality control using genotypic analysis for defining MSCs
Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood Bieback Stem Cells 2004 510 36.43 MSC-like cells can be isolated at high efficacy from full-term UC donations; we regard UC as an additional stem cell source for experimental and potentially clinical purposes
Searching for alternative sources of postnatal human mesenchymal stem cells: Candidate MSC-like cells from umbilical cord Romanov Stem Cells 2003 505 33.67 UC vasculature contains a high number of MSC-like elements forming colonies of fibroblastoid cells that may be successfully expanded in culture
Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow Baksh Stem Cells 2007 457 41.55 They compared HUCPVCs to the “gold standard” bone marrow mesenchymal stromal cells (BMSCs) with respect to their proliferation, differentiation, and transfection capacities
Adult bone marrow is a rich source of human mesenchymal ‘stem’ cells but umbilical cord and mobilized adult blood are not Wexler British Journal of Haematology 2003 384 25.6 Adult BM is a reliable source of functional cultured MSCs, but cord blood and peripheral blood stem cell collections are not
Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials Lu Haematologica 2006 381 31.75 They established a protocol to isolate abundant MSCs from human umbilical cords with a 100% success rate. The comparative study indicates that UC is an excellent alternative to BM as a source of MSCs for cell therapies.
Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice Noort Experimental Hematology 2002 315 19.69 Upon co-transplantation, MSCs, but not irradiated CD34 or B cells, promote engraftment of UCB CD34+ cells in bone marrow, spleen, and blood.
  1. BM bone marrow, HUCPVC human umbilical cord perivascular cell, MSC mesenchymal stem cell, UC umbilical cord, UCB umbilical cord blood