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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo

Fig. 2

Histological and microcomputed tomography (μCT) analysis of in vitro cultured and ectopically implanted TIs. μCT 3D rendering and cross-sections at the central zone of TIs at 2, 4, and 8 weeks showed extracellular matrix mineralization upon implantation. Histological analysis by alcian blue and hematoxylin and eosin (H&E) staining showed maintenance of fibrocartilage (FC) and chondrocyte-like cells (C) embedded in a GAG-positive matrix at 2 and 4 weeks after implantation. At 8 weeks after implantation, different tissues were formed, namely ossicle-like structures (2/6) and mineralized cartilage showing either low or no bone and bone marrow formation. Results are representative of two independent experiments, each experiment was performed in triplicate

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Stem Cell Research & Therapy

ISSN: 1757-6512