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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo

Fig. 3

Immunohistological analysis of type-I and type-II collagen deposition and contribution of human (h) cells to bone and cartilage formation by TIs. Immunohistochemistry showed co-deposition of type-II (Col2) and type-I (Col1) collagens at 2 and 4 weeks after implantation. At 8 weeks after implantation, ossicle-like structures showed reminiscences of type-II collagen deposition and contribution of human osteocalcin-positive cells to new bone tissue formation. Mineralized cartilage maintained a dual expression of type-I and type-II collagens and showed positive osteocalcin immunostaining. Results are representative of two independent experiments, each experiment was performed in triplicate

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Stem Cell Research & Therapy

ISSN: 1757-6512