Fig. 4
From: Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes
Integrative analysis of circRNAs and their parental linear transcripts. a, b Relationship between top 100 circRNAs and their parental linear transcripts in hiPSCs (iPSC) and hiPSC-CMs (CM). Ratio of circular and linear isoforms of each gene expressed in hiPSCs (c) and hiPSC-CMs (d) were converted from the relative value of circRNA (RPB)/mRNA (RPKM). Based on cutoff value for proportion of circRNAs at 75%, many more circRNAs showed a host gene-independent expression in hiPSC-CMs, compared with that in hiPSCs. Gene Ontology analyses of host genes of upregulated circRNAs in hiPSCs (e) and hiPSC-CMs (f) indicated most enriched 20 signal pathways with p < 10−5. circRNA circular RNA, CM cardiomyocyte, iPSC induced pluripotent stem cell