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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming

Fig. 5

Proximity of DNA methylation markers in DPSCs to hES and iPS cells. a Heatmap of the methylation ratio of probes for selected genes involved in pluripotency, development, endoderm, mesoderm, and ectomesenchyme in the dental- and adipose-derived somatic parental cell lines, DiPS, AiPS, and ES cells. Duplicates for each cell line. b Methylation levels of five selected developmentally associated genes for dental- and adipose-derived somatic cells with respect to iPS cells (DiPS and AiPS) and H1 hES. The probe sets for each gene analysed are: HER-FRD = cg25106036; HER-FRD = cg214999175; HOXB1 = cg24948406; MGAT3 = cg00101350; SPRY2 = cg00185066. See Additional file 1 (Table S3) for original data. c Gene model of PAX9 showing methylation levels (black being completely methylated and white completely unmethylated) at different probe sets. DPSCs show a highly similar epigenetic profile to ES and iPS cells at exons 4 and 5, but not ASCs. See Additional file 1: Table S4 for original probe sets data. AiPS adipose-derived stem cell-derived induced pluripotent stem, ASC adipose-derived stem cell, DiPS dental pulp stem cell-derived induced pluripotent stem, DPSC dental pulp stem cell, ES embryonic stem, iPS induced pluripotent stem

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