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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Extracellular matrix stiffness controls osteogenic differentiation of mesenchymal stem cells mediated by integrin α5

Fig. 7

Integrin α5/β1 and osteogenic marker expression in the presence or absence of integrin α5 blocking antibody and Akt inhibitor Triciribine. a Integrin and osteogenic marker expression assessed by qRT-PCR. b Downstream signaling protein expression of integrins monitored by western blotting and quantified by densitometry. c Signaling protein expression detected by western blotting and quantified by densitometry with or without Triciribine. *P < 0.05. **P < 0.01. n = 3. COLIAI alpha-1 chains of type I collagen, RUNX2 Runt related transcription factor 2, ERK extracellular regulated protein kinases, FAK focal adhesion kinase, GAPDH glyceraldehyde 3-phosphate dehydrogenase, GSK3β glycogen synthase kinase 3β

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