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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection

Fig. 9

BCG treatment increased the Caspase-3 activity of iPS-Mφ. iPS-Mφ and THP-1-Mφ were treated by BCG for 24 h. The upper panel illustrates the determination of the standard curve of Caspase-3, whereas the lower panel documents Caspase-3 activity. The majority (20.17 ± 0.8696 μM) of BCG-treated iPS-Mφ (BCG) became p-nitroaniline (pNA) positive. In contrast, only a small portion (14.52 ± 0.8696 uM) of iPS-Mφ untreated with BCG (Con) was pNA positive (P < 0.001).The majority (37.57 ± 1.739 uM) of BCG-treated THP-1-Mφ (BCG) became pNA positive. In contrast, only a small portion (27.57 ± 1.304 uM) of iPS-Mφ untreated with BCG (Con) was pNA positive (P < 0.001).Statistical analysis was performed by using a t test. A value of P < 0.001 represents a statistically significant difference

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