Fig. 2

Transplantation of islet-1 human mesenchymal stem cells (ISL1-hMSCs) improved cardiac function in a murine myocardial infarction (MI) model. Representative M-mode images (a) of hearts with sham surgery or MI at 4 weeks after phosphate-buffered saline (PBS), control (Ctrl)-hMSC, or ISL1-hMSC injection. Ejection fraction (b) and fractional shorting (c) at 4 weeks after ISL1-hMSC or Ctrl-hMSC transplantation were detected. Data are presented as the mean ± SD, n = 8; *p < 0.05, vs. Sham; ^#p < 0.05 vs. MI + PBS; ^&p < 0.05 vs. MI + ISL1-hMSCs. LVC left ventricular cavity, PWT posterior wall thickness