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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model

Fig. 7

Islet-1 (ISL1) overexpression enhanced the human mesenchymal stem cell (hMSC) paracrine effect by increasing insulin-like growth factor binding protein 3 (IGFBP3) secretion. A heat map display of apoptosis-related genes between ISL1-hMSCs and control (Ctrl)-hMSCs (a). GDF6, IGFBP3, TGFB1, GAS6, and INHBA gene expression in Ctrl-hMSCs and ISL1-hMSCs were determined by qPCR (b). IGFBP3 in Ctrl-hMSC conditioned medium (CM) and ISL1-hMSCs-CM determined by ELISA assay (c). Data are presented as the mean ± SD, n = 3; *p < 0.05 vs. Ctrl-hMSCs. GAPDH glyceraldehyde-3-phosphate dehydrogenase

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Stem Cell Research & Therapy

ISSN: 1757-6512