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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway

Fig. 3

H2S was required to maintain FasL expression in GMSCs. a FasL expression decreased in Cbs−/− GMSCs compared with control GMSCs as analyzed by western blot analysis. b Cbs−/− GMSCs induced less T-cell apoptosis compared with control cells. Fas-neutralized antibody treatment attenuated the ability of GMSCs to induce T-cell apoptosis (n = 5). c, d FasL overexpression restored the decreased capacity of Cbs−/− GMSC-inducing T cells in a cell–cell contact coculture system, but not in a transwell coculture system (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001. Error bars: mean ± SD. All experimental data verified in at least three independent experiments. GMSC gingiva-derived mesenchymal stem cell, FasL Fas ligand, Ab antibody

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