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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway

Fig. 5

H2S was required to maintain GMSC immunomodulation in vivo. a Schematic of GMSC infusion in DSS-induced experimental colitis mice. b GMSC infusion reduced the disease activity index (DAI) induced by DSS administration, while Cbs−/− GMSCs failed to reduce the DAI, and NaHS pretreatment partially restored the reduction of DAI by Cbs−/− GMSCs in colitis mice. c–f GMSC infusion restored mice body weight loss, Th17 cell elevation, Treg cell decrease, and histological activity increase induced by DSS, while Cbs−/− GMSCs failed to restore these clinical symptoms and histological observations in mice. NaHS pretreatment partially increased the capacity of Cbs−/− GMSCs to restore mice body weight loss, Th17 cell elevation, Treg cell decease, and histological activity increase induced by DSS. Blue triangle, inflammatory cells. *P < 0.05, **P < 0.01, ***P < 0.001. Scale bar: 100 μm (n = 6). All experimental data verified in at least three independent experiments. d days, DSS dextran sulfate sodium, MSC mesenchymal stem cell, GMSC gingiva-derived mesenchymal stem cell, IL interleukin

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